化学
级联
级联反应
催化作用
硫脲
组合化学
硝基
有机化学
色谱法
烷基
作者
Juan Mangas-Sanchez,Christian Ascaso-Alegre
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-01-10
卷期号:34 (05): 399-404
标识
DOI:10.1055/s-0042-1751403
摘要
Abstract Cascade processes are an attractive strategy to rapidly build molecular complexity and circumvent the need to isolate reaction intermediates, providing higher efficiencies into synthetic routes with lower environmental toll. We have recently developed a new method to synthesise chiral 1,4-nitro alcohols by sequentially combining three transformations in the same reaction vessel via asymmetric C–C bond formation using a chiral thiourea catalyst and a bioreduction process as key steps. 1 Introduction 2 A Chemoenzymatic Cascade to Make Chiral 1,4-Nitro Alcohols 3 Conclusions and Perspectives
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