磁刺激
渴求
甲基苯丙胺
心理学
背外侧前额叶皮质
医学
药物滥用
前额叶皮质
神经科学
刺激
上瘾
精神科
认知
作者
Xingquan Zhao,Yuqiong Zhu,Lijin Wang,Linlin Mu,Lin Zhu,Dongyan Ding,Zixuan Ren,Dengxian Yang,Hua-Jun Tang,Lei Zhang,Peipei Song,Huafeng Wei,Lei-Xin Chang,Zixu Wang,Qiang Ling,Ruifang Li‐Gao,Haibo Liu,Dongliang Jiao,Hua-shan Xu
标识
DOI:10.1016/j.psychres.2022.114904
摘要
Methamphetamine abuse is escalating worldwide. Its strong and irreversible neurotoxicity generally causes structural and functional changes in the brain. Repetitive transcranial magnetic stimulation (rTMS) as a non-invasive tool can be used to modulate neuronal activity, cortical excitability, and dopaminergic neurotransmission. This study aims to explore the efficacy of high-frequency rTMS in reducing drug craving and increasing decision-making ability for methamphetamine use disorder patients. Sixty-four methamphetamine use disorder patients were randomized to sham rTMS group and 10-Hz rTMS group. Visual analog scale (VAS) and Iowa game test (IGT) were used to evaluate drug craving and cognitive decision-making ability before and after treatment. Before the treatment, the two groups had no differences in the scores of VAS and IGT. After the intervention, VAS scores of 10-Hz rTMS group were significantly lower than that of sham rTMS group. In addition, the two groups had significant differences in the net score of IGT on block 4 and block 5, which favoured the 10-Hz rTMS group. Taken together, the present results suggest that High-frequency rTMS can be used to reduce drug craving and improve decision-making function for methamphetamine use disorder.
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