车站3
STAT蛋白
贾纳斯激酶
医学
再灌注损伤
缺血
脂质代谢
细胞凋亡
PI3K/AKT/mTOR通路
斯达
JAK-STAT信号通路
脂肪肝
信号转导
生物
内科学
细胞生物学
酪氨酸激酶
生物化学
受体
疾病
作者
Hanwen Yang,Pengpeng Zhang,Qiang Wang,Ke Cheng,Yujun Zhao
标识
DOI:10.3389/fimmu.2023.1066222
摘要
Ischemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been implicated in pathogenesis of IRI. STAT3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. STAT3 is associated with Janus kinase (JAK), phosphoinositide-3 kinase (PI3K), and heme oxygenase-1 (HO-1) in liver IRI. The STAT3 pathway plays a dual role in IRI as it can also regulate lipid metabolism which may have potential for treating IRI fatty liver. In this review, we summarize research on the function of STAT3 in liver IRI to provide references for its application in the clinic.
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