单宁酸
生物复合材料
明胶
生物相容性
自愈水凝胶
化学工程
韧性
化学
极限抗拉强度
壳聚糖
组织工程
核化学
材料科学
高分子化学
复合材料
有机化学
生物医学工程
复合数
工程类
医学
作者
Xiumei Zhang,Kejun Liu,Miao Qin,Weiwei Lan,Longfei Wang,Ziwei Liang,Xiaochun Li,Yan Wei,Yinchun Hu,Liqin Zhao,Xiaojie Lian,Di Huang
标识
DOI:10.1016/j.carbpol.2023.120702
摘要
The acidity of high tannic acid (TA) content solution can destroy the structure of protein, such as gelatin (G). This causes a big challenge to introduce abundant TA into the G-based hydrogels. Here, the G-based hydrogel system with abundant TA as hydrogen bonds provider was constructed by a “protective film” strategy. The protective film around the composite hydrogel was first formed by the chelation of sodium alginate (SA) and Ca2+. Subsequently, abundant TA and Ca2+ were successively introduced into the hydrogel system by immersing method. This strategy effectively protected the structure of the designed hydrogel. After treatment with 0.3 w/v TA and 0.06 w/v Ca2+ solutions, the tensile modulus, elongation at break and toughness of G/SA hydrogel increased about 4-, 2-, and 6-fold, respectively. Besides, G/SA-TA/Ca2+ hydrogels exhibited good water retention, anti-freezing, antioxidant, antibacterial properties and low hemolysis ratio. Cell experiments showed that G/SA-TA/Ca2+ hydrogels possessed good biocompatibility and could promote cell migration. Therefore, G/SA-TA/Ca2+ hydrogels are expected to be used in the field of biomedical engineering. The strategy proposed in this work also provides a new idea for improving the properties of other protein-based hydrogels.
科研通智能强力驱动
Strongly Powered by AbleSci AI