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Divergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms

医学
作者
Hisashi Sawada,Alan Daugherty,Hong Lü
出处
期刊:Circulation Research [Ovid Technologies (Wolters Kluwer)]
卷期号:132 (4): 449-451
标识
DOI:10.1161/circresaha.123.322511
摘要

HomeCirculation ResearchVol. 132, No. 4Divergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextDivergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms Hisashi Sawada, Alan Daugherty and Hong S. Lu Hisashi SawadaHisashi Sawada Correspondence to: Hisashi Sawada, MD, PhD, Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, 741 South Limestone St BBSRB B251 Lexington, KY 40536. Email E-mail Address: [email protected] https://orcid.org/0000-0003-0017-6236 Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, University of Kentucky, Lexington. Search for more papers by this author , Alan DaughertyAlan Daugherty https://orcid.org/0000-0003-2093-3775 Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, University of Kentucky, Lexington. Search for more papers by this author and Hong S. LuHong S. Lu Hong S. Lu, MD, PhD, Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, 741 South Limestone St BBSRB B249 Lexington, KY 40536. Email E-mail Address: [email protected] https://orcid.org/0000-0002-0577-2558 Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, University of Kentucky, Lexington. Search for more papers by this author Originally published16 Feb 2023https://doi.org/10.1161/CIRCRESAHA.123.322511Circulation Research. 2023;132:449–451This article is a commentary on the followingHomeostatic, Non-Canonical Role of Macrophage Elastase in Vascular IntegrityFootnotesFor Sources of Funding and Disclosures, see page 450.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Hisashi Sawada, MD, PhD, Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, 741 South Limestone St BBSRB B251 Lexington, KY 40536. Email hisashi.sawada@uky.eduHong S. Lu, MD, PhD, Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, 741 South Limestone St BBSRB B249 Lexington, KY 40536. Email hong.lu@uky.eduReferences1. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.Biochem Pharmacol. 2008; 75:346–359. doi: 10.1016/j.bcp.2007.07.004CrossrefMedlineGoogle Scholar2. Longo GM, Buda SJ, Fiotta N, Xiong W, Griener T, Shapiro S, Baxter BT. MMP-12 has a role in abdominal aortic aneurysms in mice.Surgery. 2005; 137:457–462. doi: 10.1016/j.surg.2004.12.004CrossrefMedlineGoogle Scholar3. Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadiere C, Renia L, et al. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice.J Clin Invest. 2010; 120:422–432. doi: 10.1172/jci38136CrossrefMedlineGoogle Scholar4. Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, Ennis TL, Shapiro SD, Senior RM, Thompson RW. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.J Clin Invest. 2000; 105:1641–1649. doi: 10.1172/jci8931CrossrefMedlineGoogle Scholar5. Curci JA, Liao S, Huffman MD, Shapiro SD, Thompson RW. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms.J Clin Invest. 1998; 102:1900–1910. doi: 10.1172/jci2182CrossrefMedlineGoogle Scholar6. Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J-J, Kukreja G, Zhang J, et al. Homeostatic, non-canonical role of macrophage elastase in vascular integrity.Circ Res. 2023; 132: 432–448doi: 10.1161/CIRCRESAHA.122.322096LinkGoogle Scholar7. Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice.J Biomech. 2022; 141:111179. doi: 10.1016/j.jbiomech.2022.111179CrossrefMedlineGoogle Scholar8. Iida Y, Xu B, Schultz GM, Chow V, White JJ, Sulaimon S, Hezi-Yamit A, Peterson SR, Dalman RL. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms.PLoS One. 2012; 7:e49642. doi: 10.1371/journal.pone.0049642CrossrefMedlineGoogle Scholar9. Xie X, Lu H, Moorleghen JJ, Howatt DA, Rateri DL, Cassis LA, Daugherty A. Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice.PLoS One. 2012; 7:e46411. doi: 10.1371/journal.pone.0046411CrossrefMedlineGoogle Scholar10. Meijer CA, Stijnen T, Wasser MN, Hamming JF, van Bockel JH, Lindeman JH; Pharmaceutical Aneurysm Stabilisation Trial Study G. Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial.Ann Intern Med. 2013; 159:815–823. doi: 10.7326/0003-4819-159-12-201312170-00007CrossrefMedlineGoogle Scholar11. Baxter BT, Matsumura J, Curci JA, McBride R, Larson L, Blackwelder W, Lam D, Wijesinha M, Terrin M; Investigators NTC. Effect of doxycycline on aneurysm growth among patients with small infrarenal abdominal aortic aneurysms: a randomized clinical trial.JAMA. 2020; 323:2029–2038. doi: 10.1001/jama.2020.5230CrossrefMedlineGoogle Scholar12. Daugherty A, Cassis LA. Mouse models of abdominal aortic aneurysms.Arterioscler Thromb Vasc Biol. 2004; 24:429–434. doi: 10.1161/01.atv.0000118013.72016.eaLinkGoogle Scholar13. Shen M, Lee J, Basu R, Sakamuri SS, Wang X, Fan D, Kassiri Z. Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.Arterioscler Thromb Vasc Biol. 2015; 35:888–898. doi: 10.1161/atvbaha.114.305115LinkGoogle Scholar14. Longo GM, Xiong W, Greiner TC, Zhao Y, Fiotti N, Baxter BT. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms.J Clin Invest. 2002; 110:625–632. doi: 10.1172/jci0215334CrossrefMedlineGoogle Scholar15. Howatt DA, Dajee M, Xie X, Moorleghen J, Rateri DL, Balakrishnan A, Da Cunha V, Johns DG, Gutstein DE, Daugherty A, et al. Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms.Circ J. 2017; 81:888–890. doi: 10.1253/circj.cj-17-0229CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesHomeostatic, Non-Canonical Role of Macrophage Elastase in Vascular IntegrityMani Salarian, et al. Circulation Research. 2023;132:432-448 February 17, 2023Vol 132, Issue 4 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.322511PMID: 36795847 Originally publishedFebruary 16, 2023 KeywordsEditorialsmatrix metalloproteinasesmacrophagesextracellular matrixangiotensin IIPDF download Advertisement

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