Altered functional connectivity of the default mode and dorsal attention network in subjective cognitive decline

默认模式网络 缘上回 任务正网络 心理学 认知 神经科学 顶叶内沟 认知功能衰退 后扣带 静息状态功能磁共振成像 前额叶皮质 皮质(解剖学) 背外侧前额叶皮质 扣带回前部 听力学 后顶叶皮质 痴呆 内科学 医学 功能磁共振成像 疾病
作者
Deokjong Lee,Jin Young Park,Woo Jung Kim
出处
期刊:Journal of Psychiatric Research [Elsevier]
卷期号:159: 165-171 被引量:10
标识
DOI:10.1016/j.jpsychires.2023.01.040
摘要

Subjective cognitive decline (SCD) is a clinical condition in which performance on standardized cognitive tests does not indicate impairment like mild cognitive impairment (MCI), but self-experienced cognitive capacity persistently declines. We aimed to explore the functional connectivity (FC) characteristics of SCD subjects compared to healthy controls and MCI patients. Resting-state functional MRI was performed on 152 elderly subjects: 65 normal controls, 62 SCD subjects, and 25 MCI patients. A seed-based FC analysis was performed to compare groups. The major brain regions of the default mode network (DMN) and dorsal attention network (DAN), large-scale brain networks disrupted in patients with dementia, were selected as seed regions. As a result, the SCD group showed stronger FC than the MCI group between DMN seeds and the supramarginal gyrus. Both the SCD and MCI groups showed stronger FC between the left lateral parietal cortex and right dorsolateral prefrontal cortex. In the FC analysis centred on DAN seeds, both the SCD and MCI groups showed weaker FC of the right posterior intraparietal sulcus in the left anterior cingulate cortex and the left insula, compared to those in the control group. Within the SCD group, hyperconnectivity between the right lateral parietal cortex and left supramarginal gyrus was significantly correlated with better performance on the Controlled Oral Word Association Test. In conclusion, the SCD group showed several DMN- and DAN-related FC alterations, similar to the MCI group, but with distinct hyperconnectivity between DMN seeds and the supramarginal gyrus. In particular, SCD has DMN-related FC patterns distinct from those of MCI that are associated with verbal fluency retention.
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