生物
效应器
免疫
翻译(生物学)
细胞生物学
激活剂(遗传学)
真核翻译
平动调节
免疫系统
遗传学
受体
信使核糖核酸
基因
作者
Tianyuan Chen,Guoyong Xu,Rui Mou,George H. Greene,Lijing Liu,Jonathan Motley,Xinnian Dong
标识
DOI:10.1016/j.chom.2023.01.014
摘要
The recognition of pathogen effectors by their cognate nucleotide-binding leucine-rich repeat (NLR) receptors activates effector-triggered immunity (ETI) in plants. ETI is associated with correlated transcriptional and translational reprogramming and subsequent death of infected cells. Whether ETI-associated translation is actively regulated or passively driven by transcriptional dynamics remains unknown. In a genetic screen using a translational reporter, we identified CDC123, an ATP-grasp protein, as a key activator of ETI-associated translation and defense. During ETI, an increase in ATP concentration facilitates CDC123-mediated assembly of the eukaryotic translation initiation factor 2 (eIF2) complex. Because ATP is required for the activation of NLRs as well as the CDC123 function, we uncovered a possible mechanism by which the defense translatome is coordinately induced during NLR-mediated immunity. The conservation of the CDC123-mediated eIF2 assembly suggests its possible role in NLR-mediated immunity beyond plants.
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