胎球蛋白
医学
妊娠期糖尿病
内科学
内分泌学
糖尿病
胰岛素抵抗
血脂
胆固醇
怀孕
产科
妊娠期
生物
生物化学
遗传学
糖蛋白
作者
Sobhy M. Yakout,Samira Hussein,Omar S. Al‐Attas,Syed Danish Hussain,Gamal M Saadawy,Nasser Al‐Daghri
出处
期刊:PubMed
日期:2023-01-01
卷期号:15 (2): 1291-1299
摘要
To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other different parameters relating to gestational diabetes in Saudi women.A total of 123 Saudi pregnant women (N: 46 GDM and N: 77 healthy control) were included in this observational study. Fasting blood samples were collected to assess serum lipids, insulin and fetuin A and fetuin B. Serum fetuin A and fetuin B were quantified by commercially available kits.The median value of fetuin A was slight lower in GDM patients [2003 pg/ml (866-3369)] than in the control group [2015 pg/ml (1060-2951)] without significant difference (P=0.95). The median value of fetuin B was also slight lower in GDM patients [3292 ng/ml (782-6740)] than the control group [3514 ng/ml (364-14854)] but without significant difference (P=0.564). There was a significant inverse correlation between fetuin B and total cholesterol in control group.The present study did not find a significant association between fetuins A and B with GDM or insulin resistance, but there was a significant inverse correlation between fetuin B and total cholesterol in the control group, reflecting good glucose control and adequate use of lipids in the nutrition of the fetus. Further research is required in the future to understand fetuin's role in the progression of GDM in Saudi women.
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