法尼甾体X受体
脂质代谢
G蛋白偶联胆汁酸受体
胆汁酸
碳水化合物代谢
FGF19型
生物化学
新陈代谢
受体
生物
化学
内分泌学
内科学
核受体
成纤维细胞生长因子
转录因子
医学
基因
作者
Huashun Yu,Ruifang Nie,Chengwu Shen
出处
期刊:Endocrine Journal
[The Japan Endocrine Society]
日期:2023-01-01
卷期号:70 (4): 359-374
标识
DOI:10.1507/endocrj.ej22-0544
摘要
In recent years, bile acids (BAs) are increasingly being appreciated as signaling molecules beyond their involvement in bile formation and fat absorption. The farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) are two dominating receptors through which BAs modulate glucose and lipid metabolism. FXR is highly expressed in the intestine and liver. GPBAR1 is highly expressed in the intestine. The present study reviews the metabolism and regulation of BAs, especially the effects of BAs on glucose and lipid metabolism by acting on FXR in the liver and intestine, and GPBAR1 in the intestine. Furthermore, it explains that fibroblast growth factor 15/19 (FGF15/19), ceramide, and glucagon like peptide-1 (GLP-1) are all involved in the signaling pathways by which BAs regulate glucose and lipid metabolism. This article aims to provide an overview of the molecular mechanisms by which BAs regulate glucose and lipid metabolism, and promote further scientific and clinical research on BAs.
科研通智能强力驱动
Strongly Powered by AbleSci AI