阿卡波糖
化学
三萜
油酸烷
糖苷
立体化学
三萜类
IC50型
山茶花
抑制性突触后电位
α-葡萄糖苷酶
传统医学
生物化学
植物
体外
酶
生物
神经科学
病理
替代医学
医学
作者
Nguyễn Thị Cúc,Ngo Anh Bang,Bùi Hữu Tài,Nguyễn Xuân Nhiệm,Phạm Hải Yến,Dương Thị Hải Yến,Truong Thi Thu Hien,Le Thi Huyen,Phan Văn Kiệm
标识
DOI:10.1002/cbdv.202300093
摘要
Five new triterpenoid glycosides, named campetelosides A-E (1-5), together with three known compounds, chikusetsusaponin IVa (6), umbellatoside B (7), and silvioside E (8) were isolated from the leaves of Camellia petelotii (Merr.) Sealy. Their chemical structures were determined by interpretations of HR-ESI-MS and NMR spectra. In addition, compounds 1-8 were evaluated for their α-glucosidase inhibitory effects. Compounds 1-3 significantly showed α-glucosidase inhibitory activity with IC50 values of 166.7±6.0, 45.9±2.6, and 395.3±10.5 μM, respectively, compared to that of the positive control, acarbose, with an IC50 value of 200.4±10.5 μM.
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