亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The safety of semaglutide in patients with depression and obesity

赛马鲁肽 肥胖 医学 萧条(经济学) 内科学 糖尿病 内分泌学 2型糖尿病 利拉鲁肽 经济 宏观经济学
作者
Ziyi Yang,Yimin Yan
出处
期刊:Obesity [Wiley]
卷期号:32 (12): 2217-2217
标识
DOI:10.1002/oby.24142
摘要

TO THE EDITOR: The bidirectional relationship between obesity and depression is complex, with each condition potentially exacerbating the other and increasing their respective pathogenic risks [(1)]. The treatment of patients with obesity and depression is particularly challenging due to the unique characteristics of this patient population. Semaglutide, an emerging treatment option, has shown significant potential in weight management and blood glucose control [(2)]. Therefore, evaluating its safety in patients with depression is crucial. The safety of semaglutide has been a topic of significant debate in recent literature for patients with both depression and obesity. The case study by Li et al. reported depressive symptoms following the use of semaglutide in patients without a history of depression, suggesting that the drug may trigger depressive episodes in susceptible individuals [(3)]. This finding has raised concerns regarding its clinical use. However, based on my clinical experience and a comprehensive review of existing literature, I remain confident in the safe use of semaglutide in patients with comorbid depression and obesity. The study by Kushner et al. confirmed the weight loss effects of semaglutide in adults with overweight and obesity, noting that its adverse event profile remained consistent regardless of antidepressant use [(1)]. Additionally, Furlan et al. supported the potential of glucagon-like peptide-1 (GLP-1) therapy in weight management for psychiatric patients. Notably, GLP-1 is not metabolized through cytochrome P450 in the liver, thereby reducing the risk of drug interactions [(4)]. The study by Chen et al. suggested potential antidepressant effects of GLP-1 receptor agonists, although the exact mechanism remains unclear [(5)]. Other reports have also reached similar conclusions, with some speculating that GLP-1 receptor agonists may help alleviate depressive symptoms. By reducing weight and improving metabolic parameters, semaglutide can enhance the quality of life for patients and mitigate the weight gain associated with psychotropic drugs. Existing evidence suggests that semaglutide is safe and effective for patients with obesity, including those who are on antidepressants [(1)]. However, clinicians should remain vigilant and monitor for potential psychological side effects, especially in patients with a history of depression or new psychiatric symptoms. Given the efficacy of semaglutide in correcting metabolic disorders and promoting weight loss, continued research is essential, particularly focusing on its long-term safety and efficacy. The authors declared no conflict of interest.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
abull完成签到,获得积分10
5秒前
8秒前
9秒前
JamesPei应助等待的松鼠采纳,获得10
17秒前
19秒前
bzg完成签到,获得积分10
19秒前
Jero完成签到 ,获得积分10
19秒前
猪猪发布了新的文献求助10
24秒前
guan发布了新的文献求助10
28秒前
杰尼龟完成签到,获得积分10
30秒前
文献菜鸟发布了新的文献求助10
36秒前
Magali发布了新的文献求助10
48秒前
NexusExplorer应助科研通管家采纳,获得10
56秒前
Dritsw应助科研通管家采纳,获得10
56秒前
Dritsw应助科研通管家采纳,获得10
56秒前
58秒前
量子星尘发布了新的文献求助10
1分钟前
所所应助杨惠子采纳,获得10
1分钟前
xsy完成签到 ,获得积分10
1分钟前
1分钟前
zoro完成签到,获得积分10
1分钟前
杨惠子发布了新的文献求助10
1分钟前
bc应助33333采纳,获得30
1分钟前
小白鸽完成签到,获得积分10
2分钟前
猪猪完成签到,获得积分10
2分钟前
2分钟前
bai123发布了新的文献求助10
2分钟前
2分钟前
量子星尘发布了新的文献求助10
2分钟前
cheng完成签到 ,获得积分10
2分钟前
2分钟前
打打应助杨惠子采纳,获得10
2分钟前
Dritsw应助科研通管家采纳,获得10
2分钟前
隐形曼青应助科研通管家采纳,获得10
2分钟前
脑洞疼应助科研通管家采纳,获得10
2分钟前
华仔应助科研通管家采纳,获得10
2分钟前
Aliya完成签到 ,获得积分10
2分钟前
3分钟前
andrele发布了新的文献求助10
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Immigrant Incorporation in East Asian Democracies 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3972713
求助须知:如何正确求助?哪些是违规求助? 3517023
关于积分的说明 11186099
捐赠科研通 3252489
什么是DOI,文献DOI怎么找? 1796477
邀请新用户注册赠送积分活动 876447
科研通“疑难数据库(出版商)”最低求助积分说明 805629