Favorable Outcome After Pegcetacoplan (Syfovre)-Associated Occlusive Retinal Vasculitis

An 86-year-old woman with advanced dry age-related macular degeneration developed occlusive retinal vasculitis 11 days after her first pegcetacoplan injection. Vision decreased from 20/30 to counting fingers. Vision improved to 20/200 with periocular and systemic steroids. Two different sets of culture plates and gram stains were all negative, but one thioglycolate broth had a light growth of Staphylococcus epidermidis and repeat vitreous culture broth grew a different organism ( Staphylococcus capitis ). After intravitreal steroids and ceftazidime, the vision ultimately improved to 20/20. Periocular and systemic steroids and antibiotics were associated with a favorable visual outcome in this patient. [ Ophthalmic Surg Lasers Imaging Retina 2025;56:XX–XX.]