J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease

医学 全国健康与营养检查调查 糖尿病 全国死亡指数 内科学 尿酸 比例危险模型 疾病 死因 队列 前瞻性队列研究 队列研究 危险系数 置信区间 人口 内分泌学 环境卫生
作者
Xinxin Zhang,Ziyue Zhang,Liyuan Gao,Bo Huang,Yue Liu,Jingqiu Cui,Junya Jia,Ming Liu
出处
期刊:Acta Diabetologica [Springer Nature]
标识
DOI:10.1007/s00592-024-02376-0
摘要

Abstract Aims The association of serum uric acid (SUA) with mortality remains unclear in patients with diabetic kidney disease (DKD). Thus, this prospective cohort study aimed to explore the association of SUA with all-cause and cardiovascular disease (CVD) mortality among patients with DKD in a large, nationally representative sample. Methods This cohort study included data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 and the National Death Index mortality data until 31 December 2019. The restricted cubic spline and the Cox proportional hazards regression were conducted to describe the association of SUA with all-cause and CVD mortality and evaluate potential nonlinear associations. Results The analysis included 3470 patients with DKD from NHANES 1999–2018. During the follow-up time of 24,633 person-years, we recorded 1489 all-cause deaths, including 542 CVD deaths. We identified a J-shaped association of SUA with all-cause and CVD mortality. The corresponding inflection points were observed at 5.1 and 5.7 mg/dL. When SUA were higher than inflection points, each 1 mg/dL increase in SUA was linked to a 13% and 22% higher risk of all-cause ( HR: 1.13; 95% CI: 1.07–1.20; P < 0.001 ) and CVD ( HR: 1.22; 95% CI: 1.06–1.41; P = 0.006 ) mortality, respectively. Conclusions This study indicated the J-shaped association of SUA with all-cause and CVD mortality in patients with DKD. The corresponding inflection points were 5.1 mg/dL for all causes and 5.7 mg/dL for CVD, respectively. More clinical randomized trials are needed to confirm the optimal uric acid-lowering target.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
狗熊也完成签到,获得积分10
刚刚
crazystone完成签到 ,获得积分10
刚刚
EmmaEmma发布了新的文献求助30
1秒前
1秒前
干净的天奇完成签到 ,获得积分10
2秒前
nkliupi发布了新的文献求助10
4秒前
灰灰发布了新的文献求助10
4秒前
4秒前
4秒前
6秒前
6秒前
昔年若许完成签到,获得积分10
7秒前
8秒前
枫糖发布了新的文献求助10
10秒前
10秒前
斯文败类应助ZIS采纳,获得10
12秒前
久久丫完成签到,获得积分10
12秒前
12秒前
EmmaEmma完成签到,获得积分10
12秒前
13秒前
14秒前
拓跋傲薇发布了新的文献求助10
14秒前
15秒前
Monicamo完成签到,获得积分10
15秒前
慕青应助苏钰采纳,获得10
16秒前
浮云客发布了新的文献求助10
16秒前
活力的静曼完成签到,获得积分10
17秒前
ssss完成签到,获得积分10
19秒前
残月初升发布了新的文献求助10
19秒前
fan发布了新的文献求助10
20秒前
20秒前
陈住气完成签到,获得积分10
22秒前
xjwang完成签到 ,获得积分10
22秒前
22秒前
Broccoli完成签到,获得积分10
23秒前
多情以山完成签到 ,获得积分10
24秒前
枫糖完成签到,获得积分10
24秒前
小蚊子完成签到,获得积分0
25秒前
gao发布了新的文献求助10
25秒前
ZIS发布了新的文献求助10
26秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Conference Record, IAS Annual Meeting 1977 610
The Laschia-complex (Basidiomycetes) 600
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3540918
求助须知:如何正确求助?哪些是违规求助? 3118164
关于积分的说明 9334037
捐赠科研通 2816035
什么是DOI,文献DOI怎么找? 1548049
邀请新用户注册赠送积分活动 721291
科研通“疑难数据库(出版商)”最低求助积分说明 712623