生物膜
MAPK/ERK通路
白色念珠菌
微生物学
生物
白色体
蛋白激酶C
细胞生物学
效应器
GTP酶
蛋白激酶A
小型GTPase
信号转导
激酶
化学
遗传学
细菌
作者
Li Mei Pang,Guisheng Zeng,Eve W. L. Chow,Xiaoli Xu,Ning Li,Yee Jiun Kok,Shu Chen Chong,Xuezhi Bi,Jiaxin Gao,Chaminda Jayampath Seneviratne,Yue Wang
出处
期刊:MBio
[American Society for Microbiology]
日期:2024-12-17
标识
DOI:10.1128/mbio.03283-24
摘要
, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. In this study, we conducted a genetic screen to identify novel genes that regulate biofilm formation in
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