Factors Governing Chemoselectivity in Alkanolamines: A Panoramic Overview

Abstract The most challenging aspect of chemical synthesis has always been attainment of high chemoselectivity levels. This review will provide a panoramic view on how the innate reactivity of two nearly reactive functional groups (− O /‐ N ) can be controlled or reversed for the chemoselective functionalisation in alkanolamines. A comprehensive compilation of reports encasing various methodologies developed to accomplish selective O / N functionalisation in amino alcohols has been documented. In this review, we go over a number of findings that have been studied in recent decades using a variety of synthetic approaches. To help us organize and emphasize the important ideas that have been emerging as a result of these research, we have concentrated on the suggested mechanistic basis of the reactions that are being surveyed.