Mapping myeloid cell function: Spatial diversity in tumor and neuronal microenvironment

In this issue of Cancer Cell, Zhong et al. explore the dual role of TREM2 in glioblastoma-associated myeloid cells, demonstrating its function in promoting inflammation at the tumor-neural interface and suppression within the tumor core, influenced by the local microenvironment. These findings open up promising prospects for advancements in neuro-oncological immunotherapy. In this issue of Cancer Cell, Zhong et al. explore the dual role of TREM2 in glioblastoma-associated myeloid cells, demonstrating its function in promoting inflammation at the tumor-neural interface and suppression within the tumor core, influenced by the local microenvironment. These findings open up promising prospects for advancements in neuro-oncological immunotherapy. Distinct roles of TREM2 in central nervous system cancers and peripheral cancersZhong et al.Cancer CellMay 23, 2024In BriefZhong et al. show that TREM2 plays an immunoprotective role prompted by central nervous system-enriched sphingolipids during glioblastoma (GBM) progression. Single-cell and spatial sequencing revealed TREM2 downregulation in GBM-infiltrating myeloid cells. TREM2 overexpression represses GBM and synergizes with anti-PD-1 therapy. This study highlights organ-specific remodeling of myeloid cell targets in cancer immunotherapy. Full-Text PDF