失调家庭
发病机制
银屑病
自噬
炎症
角质形成细胞
免疫学
医学
生物
遗传学
细胞凋亡
精神科
细胞培养
作者
Xinxin Wu,Jiankun Song,Ying Zhang,Le Kuai,Changya Liu,Xin Ma,Bin Li,Zhan Zhang,Ying Luo
标识
DOI:10.1016/j.intimp.2024.112244
摘要
Psoriasis is a common and prevalent chronic papulosquamous cutaneous disorder characterized by sustained inflammation, uncontrolled keratinocyte proliferation, dysfunctional differentiation, and angiogenesis. Autophagy, an intracellular catabolic process, can be induced in response to nutrient stress. It entails the degradation of cellular constituents through the lysosomal machinery, and its association with psoriasis has been well-documented. Nevertheless, there remains a notable dearth of research concerning the involvement of autophagy in the pathogenesis of psoriasis within human skin. This review provides a comprehensive overview of autophagy in psoriasis pathogenesis, focusing on its involvement in two key pathological manifestations: sustained inflammation and uncontrolled keratinocyte proliferation and differentiation. Additionally, it discusses potential avenues for disease management.
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