Fast freezing inhibits melanin synthesis of melanocytes by modulating the Wnt/β‐catenin signalling pathway

Wnt信号通路 连环素 细胞生物学 黑色素 化学 信号 信号通路 刺猬信号通路 连环蛋白 信号转导 生物 生物化学
作者
Siyun Wu,Xinyue Yuan,Zexin Tang,Kai Zang,Caibing Wang,Zhiyi Li,H Li,Xiyun Ye,Yongyan Dang
出处
期刊:Experimental Dermatology [Wiley]
卷期号:33 (5)
标识
DOI:10.1111/exd.15101
摘要

Abstract Skin hyperpigmentation is mainly caused by excessive synthesis of melanin; however, there is still no safe and effective therapy for its removal. Here, we found that the dermal freezer was able to improve UVB‐induced hyperpigmentation of guinea pigs without causing obvious epidermal damage. We also mimic freezing stimulation at the cellular level by rapid freezing and observed that freezing treatments <2.5 min could not decrease cell viability or induce cell apoptosis in B16F10 and Melan‐A cells. Critically, melanin content and tyrosinase activity in two cells were greatly reduced after freezing treatments. The dramatic decrease in tyrosinase activity was associated with the downregulation of MITF, TYR, TRP‐1 and TRP‐2 protein expression in response to freezing treatments for two cells. Furthermore, our results first demonstrated that freezing treatments significantly reduced the levels of p‐GSK3β and β‐catenin and the nuclear accumulation of β‐catenin in B16F10 and Melan‐A cells. Together, these data suggest that fast freezing treatments can inhibit melanogenesis‐related gene expression in melanocytes by regulating the Wnt/β‐catenin signalling pathway. The inhibition of melanin production eventually contributed to the improvement in skin hyperpigmentation induced by UVB. Therefore, fast freezing treatments may be a new alternative of skin whitening in the clinic in the future.
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