Polyp size is associated with colorectal cancer death across histologic polyp subtypes: a retrospective study of a screening colonoscopy registry

医学 结肠镜检查 结直肠癌 回顾性队列研究 普通外科 癌症 大肠息肉 结直肠癌筛查 内科学 肿瘤科
作者
Jasmin Zessner‐Spitzenberg,Elisabeth Waldmann,Lisa-Maria Rockenbauer,A. Demschik,Daniela Penz,Michael Trauner,Monika Ferlitsch
出处
期刊:Endoscopy [Georg Thieme Verlag KG]
卷期号:56 (11): 820-827 被引量:1
标识
DOI:10.1055/a-2339-0146
摘要

Abstract Background Surveillance colonoscopy after polyps have been detected at screening aims to reduce the risk for subsequent colorectal cancer, so-called post-colonoscopy colorectal cancer (PCCRC). Inconsistencies exist as to whether the risk should be stratified by histologic subtype. We aimed to compare the risk for PCCRC mortality in screening participants with sessile serrated lesions (SSLs)/traditional serrated adenomas (TSAs), hyperplastic polyps (HPPs), or conventional adenomas. Methods Screening colonoscopy registry data were linked to death registry data between 2010 and 2022. We assessed the association of PCCRC death after a diagnosis of SSL/TSA, conventional adenoma, or HPP by Cox regression, and stratified by polyp size ≥10 and <10 mm. Results 383,801 participants were included in the analysis. There were 1490 HPPs ≥10 mm (2.6%), compared with 1853 SSL/TSAs (19.6%) and 10,960 conventional adenomas (12.9%). When adjusted for polyp location, the association of polyp size ≥10 mm with PCCRC death was of similar magnitude in participants with conventional adenomas (hazard ratio [HR] 3.68, 95%CI 2.49–5.44), SSL/TSAs (HR 2.55, 95%CI 1.13–5.72), and HPPs (HR 5.01, 95%CI 2.45–10.22). Participants with HPPs mostly died of tumors in the distal colon (54.1%; n = 20), while participants with SSL/TSAs more frequently died of proximal tumors (33.3%; n = 3). Conclusions Across all histologic types, participants with polyps ≥10 mm had at least a two-fold increase in the likelihood of PCCRC death compared with those with polyps <10 mm. These data suggest that size, rather than histologic subtype, should be a determinant for risk stratification after screening colonoscopy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
laoli2022发布了新的文献求助10
1秒前
fdpb发布了新的文献求助10
2秒前
虚幻人完成签到,获得积分10
3秒前
4秒前
5秒前
7秒前
7秒前
鹿米夕zl完成签到,获得积分10
7秒前
畅快的长颈鹿完成签到 ,获得积分10
8秒前
8秒前
小小鱼完成签到,获得积分10
9秒前
10秒前
10秒前
谦让寄容发布了新的文献求助10
10秒前
11秒前
木鱼完成签到,获得积分10
14秒前
科目三应助kimlian采纳,获得10
14秒前
Tigher完成签到,获得积分10
14秒前
团子发布了新的文献求助10
15秒前
上官若男应助清秀的梦菡采纳,获得10
15秒前
16秒前
16秒前
苗条馒头完成签到,获得积分10
16秒前
18秒前
烟花应助小何采纳,获得10
19秒前
星迹一帆完成签到 ,获得积分10
21秒前
璇儿发布了新的文献求助10
21秒前
WSGQT完成签到,获得积分10
21秒前
珞启启完成签到,获得积分20
22秒前
852应助红红采纳,获得10
22秒前
闪闪龙猫应助鹿米夕zl采纳,获得10
22秒前
MADAO发布了新的文献求助10
23秒前
优美的山晴完成签到,获得积分10
23秒前
24秒前
24秒前
25秒前
情怀应助奔跑的胰岛素采纳,获得10
25秒前
就晚安喽完成签到 ,获得积分10
28秒前
zhangshaojie完成签到,获得积分10
29秒前
29秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Effect of reactor temperature on FCC yield 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1020
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Mission to Mao: Us Intelligence and the Chinese Communists in World War II 600
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3304319
求助须知:如何正确求助?哪些是违规求助? 2938315
关于积分的说明 8488060
捐赠科研通 2612780
什么是DOI,文献DOI怎么找? 1426863
科研通“疑难数据库(出版商)”最低求助积分说明 662866
邀请新用户注册赠送积分活动 647369