医学
炎症
血管平滑肌
MFN2型
衰老
生物
病理
细胞生物学
免疫学
平滑肌
内科学
线粒体融合
线粒体DNA
生物化学
基因
作者
Chenglong Fang,Lihong Du,Shang Gao,Yuexin Chen,Zuoguan Chen,Zhiyuan Wu,Lili Li,Jing Li,Xiaofeng Zeng,Mengtao Li,Yongjun Li,Xinping Tian
标识
DOI:10.1136/ard-2024-225630
摘要
Arterial wall inflammation and remodelling are the characteristic features of Takayasu's arteritis (TAK). It has been proposed that vascular smooth muscle cells (VSMCs) are the main targeted cells of inflammatory damage and participate in arterial remodelling in TAK. Whether VSMCs are actively involved in arterial wall inflammation has not been elucidated. Studies have shown that cellular senescence in tissue is closely related to local inflammation persistence. We aimed to investigate whether VSMCs senescence contributes to vascular inflammation and the prosenescent factors in TAK.
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