Biological basis and treatment of frailty and sarcopenia

肌萎缩 医学 痴呆 老年学 疾病 心力衰竭 预期寿命 蛋白质稳态 内科学 人口 生物 环境卫生 遗传学
作者
Ryosuke Sato,Mirela Vatic,Guilherme Wesley Peixoto da Fonseca,Stefan D. Anker,Stephan von Haehling
出处
期刊:Cardiovascular Research [Oxford University Press]
卷期号:120 (9): 982-998
标识
DOI:10.1093/cvr/cvae073
摘要

Abstract In an ageing society, the importance of maintaining healthy life expectancy has been emphasized. As a result of age-related decline in functional reserve, frailty is a state of increased vulnerability and susceptibility to adverse health outcomes with a serious impact on healthy life expectancy. The decline in skeletal muscle mass and function, also known as sarcopenia, is key in the development of physical frailty. Both frailty and sarcopenia are highly prevalent in patients not only with advanced age but also in patients with illnesses that exacerbate their progression like heart failure (HF), cancer, or dementia, with the prevalence of frailty and sarcopenia in HF patients reaching up to 50–75% and 19.5–47.3%, respectively, resulting in 1.5–3 times higher 1-year mortality. The biological mechanisms of frailty and sarcopenia are multifactorial, complex, and not yet fully elucidated, ranging from DNA damage, proteostasis impairment, and epigenetic changes to mitochondrial dysfunction, cellular senescence, and environmental factors, many of which are further linked to cardiac disease. Currently, there is no gold standard for the treatment of frailty and sarcopenia, however, growing evidence supports that a combination of exercise training and nutritional supplement improves skeletal muscle function and frailty, with a variety of other therapies being devised based on the underlying pathophysiology. In this review, we address the involvement of frailty and sarcopenia in cardiac disease and describe the latest insights into their biological mechanisms as well as the potential for intervention through exercise, diet, and specific therapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可爱的函函应助小小采纳,获得10
刚刚
李子木完成签到,获得积分20
刚刚
1秒前
小丸子完成签到 ,获得积分10
1秒前
69发布了新的文献求助10
1秒前
星河完成签到,获得积分10
1秒前
1秒前
托物言宇发布了新的文献求助10
1秒前
ZZZ发布了新的文献求助10
2秒前
FashionBoy应助123采纳,获得10
2秒前
3秒前
3秒前
qhy完成签到,获得积分10
3秒前
科研醉汉完成签到,获得积分10
3秒前
wangndk完成签到,获得积分10
5秒前
Hui_2023发布了新的文献求助10
5秒前
WYN完成签到 ,获得积分10
5秒前
小蘑菇应助matt采纳,获得10
5秒前
大个应助可可采纳,获得10
6秒前
zwhy完成签到 ,获得积分10
6秒前
934834完成签到,获得积分10
6秒前
rrt完成签到,获得积分10
6秒前
zhouzhou完成签到,获得积分10
6秒前
一叶扁舟完成签到,获得积分10
7秒前
7秒前
8秒前
mint发布了新的文献求助10
8秒前
calendar应助lddd采纳,获得10
9秒前
执着的难破完成签到 ,获得积分0
10秒前
Legend_完成签到,获得积分10
10秒前
11秒前
彭于晏应助胖胖采纳,获得10
11秒前
ruixuekuangben完成签到,获得积分10
12秒前
叶子完成签到 ,获得积分10
12秒前
Holly完成签到,获得积分10
13秒前
彩色的老五完成签到,获得积分10
14秒前
fat完成签到,获得积分10
14秒前
15秒前
15秒前
蒜命师关注了科研通微信公众号
15秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081744
求助须知:如何正确求助?哪些是违规求助? 2734831
关于积分的说明 7534536
捐赠科研通 2384276
什么是DOI,文献DOI怎么找? 1264252
科研通“疑难数据库(出版商)”最低求助积分说明 612606
版权声明 597600