Asymmetric difluoroalkylation via Michael addition of in situ generated difluoroenol intermediate

A dirhodium and chiral Zn-complex co-catalyzed asymmetric difluoroalkylation of isatylidene malononitriles via Michael-type interception of α,α-difluoroenol species, which generated in situ from trifluoromethyl diazo compounds and water in the presence...