NAD+激酶
神经退行性变
神经保护
变性(医学)
肌萎缩侧索硬化
疾病
视网膜变性
程序性细胞死亡
癌症研究
神经科学
细胞生物学
生物
医学
酶
生物化学
病理
细胞凋亡
视网膜
作者
Mitsuko Masutani,Masanao Miwa,Palmiro Poltronieri
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2023-03-22
卷期号:23 (12): 1351-1354
被引量:1
标识
DOI:10.2174/1871520623666230320153757
摘要
Neuroprotection is one of the hot topics in medicine. Alzheimer's disease, amyotrophic lateral sclerosis, retinal pigment epithelial (RPE) degeneration, and axonal degeneration have been studied for the involvement of NAD depletion. Localized NAD+ depletion could lead to overactivation and crowding of local NAD+ salvage pathways. It has been stated that NAD+ depletion caused by PARPs and PAR cycling has been related to metabolic diseases and cancer. Additionally, it is now acknowledged that SARM1 dependent NAD+ depletion causes axon degeneration. New targeted therapeutics, such as SARM1 inhibitors, and NAD+ salvage drugs will help alleviate the dysfunctions affecting cell life and death in neurodegeneration as well as in metabolic diseases and cancer.
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