DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
半胱氨酸
化学
生物化学
酶
作者
Mariko Takahashi,Harrison B. Chong,Siwen Zhang,Matthew J. Lazarov,Stefan Harry,Michelle Maynard,Ryan R. White,Heather E. Murrey,Brendan Hilbert,Jason R. Neil,Magdy Gohar,Maolin Ge,Junbing Zhang,Benedikt R. Dürr,Gregory V. Kryukov,Chih‐Chiang Tsou,Natasja Brooijmans,Aliyu Sidi Omar Alghali,Karla Rubio,Antonio Vilanueva
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed
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(2025-6-4)
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