Lanostane triterpenoids from artificially cultivated fruiting bodies of Ganoderma wiiroense

Seven undescribed lanostane triterpenoids (1–7) were isolated from artificially cultivated fruiting bodies of Ganoderma wiiroense, strain TBRC-BCC 60613. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The C-23 absolute configuration of 1 was determined to be 23 S using the modified Mosher's method. The isolated compounds were evaluated for their antitubercular and antimalarial activities. Compound 7 showed activity against Mycobacterium tuberculosis H37Ra (MIC 50 μg/ml).