亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway

红景天苷 PI3K/AKT/mTOR通路 DU145型 蛋白激酶B 癌症研究 细胞凋亡 细胞生长 细胞迁移 前列腺癌 信号转导 活力测定 医学 药理学 化学 癌症 生物 细胞 细胞生物学 内科学 生物化学 LNCaP公司
作者
R Liu,Teng-Fei Ma,Qin Yang,Wenchang Xiao,Lu Yin,Miao Yin,Jinsong Zhang,Chaoyi Wang
出处
期刊:Cancer Biomarkers [IOS Press]
卷期号:38 (3): 321-332 被引量:3
标识
DOI:10.3233/cbm-220454
摘要

BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies in men. PCa is difficult to detect in its early stages, and most patients are diagnosed in the middle to late stages. At present, drug therapy for advanced PCa is still insufficient. Some patients develop drug resistance in the later stage of therapy, which leads to tumor recurrence, metastasis and even treatment failure. Therefore, it is crucial to find new and effective drugs to treat prostate cancer. OBJECTIVE: The aim of this study was to investigate the anti-cancer effect of salidroside, an active ingredient in a traditional Chinese herbal medicine, on PCa. METHODS: Two human PCa cell lines, PC3 and DU145, were cultured and treated with salidroside. Cell viability and proliferation ability were analyzed through CCK-8 and colony assays, and cell migration ability was detected by Transwell and Scratch assays. RT-PCR and WB were used to detected the expression levels of moleculars related to cell proliferation, apoptosis, migration, and AKT signaling pathway. Forthmore, we performed rescue experiments with agonist to verify the affected signaling pathway. RESULTS: Salidroside inhibited the proliferation, colony formation, and migration of PCa cells. Meanwhile, apoptosis of PCa cells was enhanced. Moreover, salidroside inhibited PI3K/AKT pathway in PCa cells. The treatment of AKT agonist 740Y-P abrogated the inhibitory effect of salidroside on the PI3K/AKT signaling pathway. CONCLUSIONS: Our study demonstrated that in PCa cells, salidroside inhibites proliferation and migration and promots apoptosis via inhibiting PI3K/AKT pathway.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英姑应助李梓权采纳,获得10
1秒前
oleskarabach完成签到,获得积分20
15秒前
Noob_saibot完成签到,获得积分10
15秒前
15秒前
oleskarabach发布了新的文献求助10
20秒前
星启发布了新的文献求助10
20秒前
李梓权发布了新的文献求助10
20秒前
26秒前
LL完成签到 ,获得积分10
27秒前
武大帝77完成签到 ,获得积分10
48秒前
1分钟前
科研牛马完成签到,获得积分10
1分钟前
Nothing789完成签到,获得积分10
1分钟前
1分钟前
2分钟前
见识到了完成签到,获得积分10
2分钟前
星启发布了新的文献求助10
2分钟前
2分钟前
见识到了发布了新的文献求助10
2分钟前
万能图书馆应助星启采纳,获得10
2分钟前
oscar完成签到,获得积分10
2分钟前
fighting发布了新的文献求助10
2分钟前
3分钟前
3分钟前
小廷完成签到,获得积分10
3分钟前
JamesPei应助见识到了采纳,获得10
3分钟前
杭采蓝完成签到 ,获得积分10
3分钟前
3分钟前
messi发布了新的文献求助10
3分钟前
碘伏完成签到 ,获得积分10
3分钟前
Jasper应助messi采纳,获得30
3分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
messi完成签到,获得积分10
4分钟前
难过代柔完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
4分钟前
4分钟前
xiezizai发布了新的文献求助10
4分钟前
高分求助中
Exploring Mitochondrial Autophagy Dysregulation in Osteosarcoma: Its Implications for Prognosis and Targeted Therapy 4000
Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms 2000
Evolution 1100
How to Create Beauty: De Lairesse on the Theory and Practice of Making Art 1000
Research Methods for Sports Studies 1000
Gerard de Lairesse : an artist between stage and studio 670
T/CAB 0344-2024 重组人源化胶原蛋白内毒素去除方法 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 免疫学 病理 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 2980227
求助须知:如何正确求助?哪些是违规求助? 2641258
关于积分的说明 7124610
捐赠科研通 2274189
什么是DOI,文献DOI怎么找? 1206331
版权声明 591981
科研通“疑难数据库(出版商)”最低求助积分说明 589477