Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway

红景天苷 PI3K/AKT/mTOR通路 DU145型 蛋白激酶B 癌症研究 细胞凋亡 细胞生长 细胞迁移 前列腺癌 信号转导 活力测定 医学 药理学 化学 癌症 生物 细胞 细胞生物学 内科学 生物化学 LNCaP公司
作者
R Liu,Teng-Fei Ma,Qin Yang,Wenchang Xiao,Lu Yin,Miao Yin,Jinsong Zhang,Chaoyi Wang
出处
期刊:Cancer Biomarkers [IOS Press]
卷期号:38 (3): 321-332 被引量:3
标识
DOI:10.3233/cbm-220454
摘要

BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies in men. PCa is difficult to detect in its early stages, and most patients are diagnosed in the middle to late stages. At present, drug therapy for advanced PCa is still insufficient. Some patients develop drug resistance in the later stage of therapy, which leads to tumor recurrence, metastasis and even treatment failure. Therefore, it is crucial to find new and effective drugs to treat prostate cancer. OBJECTIVE: The aim of this study was to investigate the anti-cancer effect of salidroside, an active ingredient in a traditional Chinese herbal medicine, on PCa. METHODS: Two human PCa cell lines, PC3 and DU145, were cultured and treated with salidroside. Cell viability and proliferation ability were analyzed through CCK-8 and colony assays, and cell migration ability was detected by Transwell and Scratch assays. RT-PCR and WB were used to detected the expression levels of moleculars related to cell proliferation, apoptosis, migration, and AKT signaling pathway. Forthmore, we performed rescue experiments with agonist to verify the affected signaling pathway. RESULTS: Salidroside inhibited the proliferation, colony formation, and migration of PCa cells. Meanwhile, apoptosis of PCa cells was enhanced. Moreover, salidroside inhibited PI3K/AKT pathway in PCa cells. The treatment of AKT agonist 740Y-P abrogated the inhibitory effect of salidroside on the PI3K/AKT signaling pathway. CONCLUSIONS: Our study demonstrated that in PCa cells, salidroside inhibites proliferation and migration and promots apoptosis via inhibiting PI3K/AKT pathway.
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