医学
阶段(地层学)
接收机工作特性
肺癌
比例危险模型
内科学
肿瘤科
基底细胞
肺
癌
生存分析
倍增时间
细胞
古生物学
生物
遗传学
作者
Kenta Nakahashi,Marina Nakatsuka,Makoto Endoh,Satoshi Shiono
出处
期刊:Journal of Thoracic Disease
[AME Publishing Company]
日期:2023-07-01
卷期号:15 (7): 3849-3859
被引量:1
摘要
Tumor volume doubling time (VDT) has been shown to predict prognosis in various non-small cell lung carcinoma with scant evidence for lung squamous cell carcinoma (SCC). The purpose of this study was to investigate the prognostic value of tumor VDT in resected lung SCCs.In this study, subjects were 51 patients who underwent lobectomy for clinical stage I SCC of the peripheral lung at our institution between January 2006 and April 2020. Univariable and multivariable analyses of overall survival (OS) and recurrence-free survival (RFS) were performed using the Cox proportional hazards model. The Kaplan-Meier method was used to create OS and RFS curves and to determine statistical significance. The cut-off value of VDT was defined by receiver operating characteristic (ROC) curve analysis on survival.Multivariable analysis found only VDT (HR, 0.990; 95% CI: 0.979-0.997) to be an independent predictor of OS. Also, only VDT (HR, 0.989; 95% CI: 0.978-0.995) was an independent predictor of RFS. The 5-year OS rates were 88.4% and 30.4% in the long (≥150 days) and short (<150 days) VDT groups, respectively (P=0.002). The 5-year RFS rates were 88.8% and 26.5% in the long (≥150 days) and short (<150 days) VDT groups, respectively (P<0.001).Tumor VDT was found to be a useful prognostic predictor in clinical stage I lung SCC in this study.
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