Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus

维生素D与神经学 医学 内科学 系统性红斑狼疮 维生素 维生素D缺乏 逻辑回归 内分泌学 红斑狼疮 痹症科 疾病 免疫学 抗体
作者
Ji‐Won Kim,Wook‐Young Baek,Ju‐Yang Jung,Hyoun‐Ah Kim,Cheong in Yang,S I. Kim,Chang‐Hee Suh
出处
期刊:European Journal of Clinical Investigation [Wiley]
卷期号:54 (1) 被引量:2
标识
DOI:10.1111/eci.14092
摘要

Abstract Background Seasonal variation and sunlight exposure can impact serum vitamin D levels, potentially influencing lupus symptoms. We investigated seasonal vitamin D levels and their correlation with clinical manifestations and disease activity in systemic lupus erythematosus (SLE). Methods Serum 25(OH) vitamin D3 (25(OH)D3) levels were categorised as deficient (25(OH)D3 < 10 ng/mL), insufficient (10–30 ng/mL) and sufficiency (>30 ng/mL) in participants analysed in winter ( n = 407) and summer ( n = 377). Logistic regression analysis was performed to assess the impact of vitamin D levels on achieving a lupus low disease activity state (LLDAS), stratified by season. Results The mean serum 25(OH)D3 levels differed significantly between the winter and summer measurement groups (22.4 vs. 24.2 ng/mL; p = .018). The prevalences of vitamin D deficiency, insufficiency and sufficiency in the winter group were 12.8%, 66.6% and 20.6%, respectively, compared with 4.5%, 67.9% and 27.6% in the summer group. Achieving LLDAS was highest in the vitamin D sufficiency group (winter: 56.6%, summer: 55%) and lowest in the vitamin D deficiency group (winter: 15.4%, summer: 13.6%), with significant differences (all p < .001). Multivariate analysis identified SLE disease activity index ≤4, normal anti‐double‐stranded DNA and vitamin D sufficiency as significant factors for achieving LLDAS in both seasons. Conclusions Sufficient vitamin D levels are important for achieving LLDAS in patients with SLE during winter and summer. Therefore, physicians should pay attention to the adequacy of vitamin D levels and consider recommending vitamin D supplementation for patients with vitamin D insufficiency.
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