已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Single‐dose oral azithromycin prophylaxis in planned vaginal delivery for sepsis prevention: A systematic review and meta‐analysis of randomized controlled trials

医学 相对风险 阿奇霉素 随机对照试验 安慰剂 荟萃分析 子宫内膜炎 置信区间 科克伦图书馆 入射(几何) 需要治疗的数量 败血症 内科学 怀孕 产科 抗生素 遗传学 替代医学 物理 光学 病理 微生物学 生物
作者
Laura F. Crosara,P. Orsini,Karine Eskandar,Samira Mohamad Khalil,Graciela Castilhos,P. A. M. Strahl,Tanize Milbradt,Chris Elizabeth Philip
出处
期刊:International journal of gynaecology and obstetrics [Wiley]
卷期号:165 (1): 107-116 被引量:1
标识
DOI:10.1002/ijgo.15124
摘要

Abstract Introduction The use of oral azithromycin (AZI) as a preventive measure against postpartum infections of planned vaginal births has garnered a lot of interest in recent years and has been the subject of many randomized controlled trials (RCTs). However, the results from these trials have not been consistent. Therefore, we aim to perform a systematic review and meta‐analysis to determine whether the use of a single‐dose of oral AZI is clinically significant. Methods We systematically searched PubMed, Embase, and Cochrane Central for RCTs from May to June 2023, comparing a single dose of oral AZI with placebo in patients undergoing planned vaginal delivery at a minimum of 28 weeks of gestational age. The main outcomes were puerperal and neonatal sepsis. Statistical analyses were performed using Review Manager 5.4.1 (Cochrane Collaboration). Heterogeneity was assessed with I 2 statistics. Results Four RCTs were included (mothers, n = 42 235; newborns n = 42 492). Approximately 49.8% of mothers received a single dose of oral AZI for sepsis prophylaxis. Compared with placebo, AZI significantly reduced the incidence of puerperal sepsis (risk ratio [RR], 0.65 [95% confidence interval (CI), 0.55–0.77]; P < 0.001), mastitis or breast abscess (RR, 0.58 [95% CI, 0.42–0.79]; P < 0.001), endometritis (RR, 0.65 [95% CI, 0.54–0.77]; P < 0.001), wound infection (RR, 0.81 [95% CI, 0.69–0.96]; P = 0.013), infection rate (RR, 0.62 [95% CI, 0.51–0.76]; P < 0.001), and fever (RR, 0.50 [95% CI, 0.28–0.89]; P = 0.018) in mothers. No statistically significant differences were identified between groups regarding maternal all‐cause mortality and the use of prescribed postpartum antibiotics. Similarly, no statistical differences were noted in the neonatal group regarding sepsis, infection rate, and all‐cause mortality. Conclusion AZI appears to be an effective preventive measure against many postpartum infections in mothers but a substantial impact on neonatal outcomes has not yet been conclusively observed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
对流域发布了新的文献求助10
刚刚
农学小王完成签到 ,获得积分10
刚刚
2秒前
852应助Steve采纳,获得10
3秒前
小马甲应助安珀采纳,获得10
4秒前
内向忆南发布了新的文献求助10
5秒前
12秒前
gjww完成签到,获得积分0
13秒前
Odile完成签到 ,获得积分10
14秒前
15秒前
kkscanl完成签到 ,获得积分10
15秒前
Nakacoke77完成签到,获得积分10
17秒前
WRX发布了新的文献求助10
20秒前
30秒前
Ethan完成签到 ,获得积分0
30秒前
zzzyyy应助Nos_Edan采纳,获得50
37秒前
生姜批发刘哥完成签到 ,获得积分10
38秒前
tombo100完成签到,获得积分10
41秒前
充电宝应助科研通管家采纳,获得10
43秒前
彭于晏应助科研通管家采纳,获得10
43秒前
英俊的铭应助科研通管家采纳,获得10
43秒前
52秒前
13654135090完成签到,获得积分10
55秒前
追三完成签到 ,获得积分10
59秒前
小马甲应助内向忆南采纳,获得10
1分钟前
liu发布了新的文献求助10
1分钟前
1分钟前
九九030211完成签到,获得积分20
1分钟前
athena发布了新的文献求助30
1分钟前
九九030211发布了新的文献求助10
1分钟前
zzzyyy发布了新的文献求助100
1分钟前
GAO完成签到,获得积分10
1分钟前
felix发布了新的文献求助10
1分钟前
11128完成签到 ,获得积分10
1分钟前
无聊的人完成签到 ,获得积分10
1分钟前
汉堡包应助魔幻蓉采纳,获得10
1分钟前
1分钟前
伊洛发布了新的文献求助30
1分钟前
liu完成签到,获得积分20
1分钟前
zzzyyy完成签到,获得积分10
1分钟前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3136964
求助须知:如何正确求助?哪些是违规求助? 2787951
关于积分的说明 7783990
捐赠科研通 2443991
什么是DOI,文献DOI怎么找? 1299549
科研通“疑难数据库(出版商)”最低求助积分说明 625477
版权声明 600954