孟德尔随机化
肠道菌群
斑秃
全基因组关联研究
生物
因果关系(物理学)
失调
真细菌
遗传学
内科学
医学
免疫学
单核苷酸多态性
基因型
细菌
遗传变异
基因
物理
量子力学
作者
Wen Xu,Li Zhang,Xiuzu Song
出处
期刊:Research Square - Research Square
日期:2023-07-31
标识
DOI:10.21203/rs.3.rs-3165175/v1
摘要
Abstract Background Recent cross-sectional analyses have disclosed associations between gut microbiota diversity and alopecia areata (AA). However, the definitive causal influence of gut microbiota on AA remains undetermined. Methods To probe the potential causal association between gut microbiota and AA, we leveraged data from Genome-wide association studies (GWAS) conducted by both the MiBioGen and FinnGen consortiums. The dataset included information on gut microbiota (n = 13,266) and AA (n = 211,428), extracted from earlier observational studies. We applied five statistical techniques in our Mendelian randomization (MR) analysis to infer the causality between gut microbiota and AA. Conversely, we undertook a reverse MR analysis to ascertain whether AA causally impacts gut microbiota. The validity of the MR analysis was evaluated via sensitivity analysis. Results The IVW assessment implied a protective influence against AA from Butyricimonas (OR = 0.37, 95% CI: 0.18–0.77, p = 0.01), Enterorhabdus (OR = 0.40, 95% CI: 0.16–0.95, p = 0.04), Eubacterium (xylanophilum group) (OR = 0.36, 95% CI: 0.15–0.84, p = 0.02), and Phascolarctobacterium (OR = 0.37, 95% CI: 0.15–0.91, p = 0.03). In contrast, Ruminococcaceae UCG003 emerged as a risk factor for AA (OR = 2.79, 95% CI: 1.27–6.14, p = 0.01). Our reverse MR exploration did not discern any statistically significant causal association between AA and gut microbiota. Similarly, no significant heterogeneity of IVs or horizontal pleiotropy was observed. Conclusions This current study offers compelling evidence for a probable causality between certain gut microbiota and AA, thus providing vital insights into its pathogenesis and potential preventative and therapeutic approaches.
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