Microvascular invasion-negative hepatocellular carcinoma: Prognostic value of qualitative and quantitative Gd-EOB-DTPA MRI analysis

医学 列线图 肝细胞癌 磁共振成像 内科学 多元分析 逻辑回归 单变量分析 胃肠病学 临床终点 对数秩检验 生存分析 放射科 核医学 随机对照试验
作者
Leyao Wang,Meng Liang,Bing Feng,Dengfeng Li,Rong Cong,Zhaowei Chen,Sicong Wang,Xiaohong Ma,Xinming Zhao
出处
期刊:European Journal of Radiology [Elsevier]
卷期号:168: 111146-111146
标识
DOI:10.1016/j.ejrad.2023.111146
摘要

Objectives The purpose of this study was to establish a model for predicting the prognosis of patients with microvascular invasion (MVI)-negative hepatocellular carcinoma (HCC) based on qualitative and quantitative analyses of Gd-EOB-DTPA magnetic resonance imaging (MRI). Materials and methods Consecutive patients with MVI-negative HCC who underwent preoperative Gd-EOB-DTPA MRI between January 2015 and December 2019 were retrospectively enrolled. In total, 122 patients were randomly assigned to the training and validation groups at a ratio of 7:3. Univariate and multivariate logistic regression analyses were performed to identify significant clinical parameters and MRI features, including quantitative and qualitative parameters associated with prognosis, which were incorporated into a predictive nomogram. The end-point of this study was recurrence-free survival. Outcomes were compared between groups using the Kaplan–Meier method with the log-rank test. Results During a median follow-up period of 58.86 months, 38 patients (31.15 %) experienced recurrence. Multivariate analysis revealed that lower relative enhancement ratio (RER), hepatobiliary phase hypointensity without arterial phase hyperenhancement, Liver Imaging Reporting and Data System category, mild-moderate T2 hyperintensity, and higher aspartate aminotransferase levels were risk factors associated with prognosis and then incorporated into the prognostic model. C-indices for training and validation groups were 0.732 and 0.692, respectively. The most appropriate cut-off value for RER was 1.197. Patients with RER ≤ 1.197 had significantly higher postoperative recurrence rates than those with RER > 1.197 (p = 0.004). Conclusion The model integrating qualitative and quantitative imaging parameters and clinical parameters satisfactorily predicted the prognosis of patients with MVI-negative HCC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
叶黄戍发布了新的文献求助10
刚刚
ranranran完成签到,获得积分10
刚刚
1秒前
金蕊完成签到,获得积分10
2秒前
kls完成签到,获得积分10
2秒前
小刘完成签到,获得积分10
2秒前
2秒前
SciGPT应助33采纳,获得10
3秒前
Jyy77完成签到 ,获得积分10
3秒前
4秒前
hajy完成签到 ,获得积分10
5秒前
一笑奈何完成签到,获得积分10
6秒前
善良安梦发布了新的文献求助30
8秒前
小虎发布了新的文献求助10
8秒前
叶黄戍完成签到,获得积分10
8秒前
Akim应助家嵩采纳,获得10
9秒前
123完成签到,获得积分10
13秒前
14秒前
wg发布了新的文献求助10
15秒前
虚幻采枫发布了新的文献求助10
16秒前
追云发布了新的文献求助10
16秒前
16秒前
16秒前
傢誠发布了新的文献求助10
16秒前
科研通AI2S应助内向的金鱼采纳,获得10
19秒前
不配.应助littleE采纳,获得20
22秒前
庸人自扰完成签到,获得积分10
23秒前
细心道消发布了新的文献求助10
23秒前
小虎完成签到,获得积分10
23秒前
24秒前
爆米花应助wangheng采纳,获得10
24秒前
25秒前
脑洞疼应助科研小迷糊采纳,获得10
27秒前
我瞎蒙发布了新的文献求助30
28秒前
29秒前
29秒前
细心道消完成签到,获得积分10
32秒前
乐乐应助我瞎蒙采纳,获得10
33秒前
小刘发布了新的文献求助10
33秒前
傢誠完成签到,获得积分10
35秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3143731
求助须知:如何正确求助?哪些是违规求助? 2795219
关于积分的说明 7813671
捐赠科研通 2451210
什么是DOI,文献DOI怎么找? 1304353
科研通“疑难数据库(出版商)”最低求助积分说明 627221
版权声明 601400