软骨发生
间充质干细胞
骨关节炎
材料科学
软骨
细胞内
生物医学工程
纳米技术
细胞
干细胞
细胞生物学
化学
医学
生物
解剖
病理
生物化学
替代医学
作者
Cuijun Deng,Zhenguang Li,Laiya Lu,Huina Zhang,Runzhi Chen,Yali Liu,Yifan Tong,Orion Fan,Wenfei Huang,Yi Sun,Feng Yin,Yu Cheng
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-10-20
卷期号:17 (21): 21690-21707
被引量:11
标识
DOI:10.1021/acsnano.3c06909
摘要
Abnormal mechanical loading often leads to the progressive degradation of cartilage and causes osteoarthritis (OA). Although multiple mechanoresponsive strategies based on biomaterials have been designed to restore healthy cartilage microenvironments, methods to remotely control the on-demand mechanical forces for cartilage repair pose significant challenges. Here, a magneto-mechanically controlled mesenchymal stem cell (MSC) platform, based on the integration of intercellular mechanical communication and intracellular mechanosignaling processes, is developed for OA treatment. MSCs loaded with antioxidative melanin@Fe3O4 magnetic nanoparticles (Magcells) rapidly assemble into highly ordered cell clusters with enhanced cell-cell communication under a time-varying magnetic field, which enables long-term retention and differentiation of Magcells in the articular cavity. Subsequently, via mimicking the gait cycle, chondrogenesis can be further enhanced by the dynamic activation of mechanical signaling processes in Magcells. This sophisticated magneto-mechanical actuation strategy provides a paradigm for developing mechano-therapeutics to repair cartilage in OA treatment.
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