生物
限制
癌症
癌症治疗
免疫系统
计算生物学
模块化设计
肠道细菌
合成生物学
清脆的
生物信息学
微生物群
免疫学
遗传学
计算机科学
基因
工程类
操作系统
机械工程
作者
Vishnu Raman,C. Deshpande,Shradha Khanduja,Lars M. Howell,Aleyde Van Eynde,Neil S. Forbes
标识
DOI:10.1016/j.chom.2023.09.006
摘要
Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce their effectiveness. To increase efficacy, bacterial delivery platforms have been developed that improve safety and prolong treatment. Bacteria are a unique class of therapy that selectively colonizes most solid tumors. As delivery vehicles, bacteria have been genetically modified to express a range of therapies that match multiple cancer indications. In this review, we describe a modular "build-a-bug" method that focuses on five design characteristics: bacterial strain (chassis), therapeutic compound, delivery method, immune-modulating features, and genetic control circuits. We emphasize how fundamental research into gut microbe pathogenesis has created safe bacterial therapies, some of which have entered clinical trials. The genomes of gut microbes are fertile grounds for discovery of components to improve delivery and modulate host immune responses. Future work coupling these delivery vehicles with insights from gut microbes could lead to the next generation of microbial cancer therapy.
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