Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long‐Term Functional Stability and Controlled Release of Biomacromolecules

图书馆学 管理 计算机科学 经济
作者
Timothy M. O’Shea,Matthew J. Webber,Alex A. Aimetti,Róbert Langer
出处
期刊:Advanced Healthcare Materials [Wiley]
卷期号:4 (12): 1802-1812 被引量:24
标识
DOI:10.1002/adhm.201500334
摘要

Advanced Healthcare MaterialsVolume 4, Issue 12 p. 1802-1812 Communication Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules Timothy M. O'Shea, Timothy M. O'Shea Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USASearch for more papers by this authorMatthew J. Webber, Matthew J. Webber David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115 USASearch for more papers by this authorAlex A. Aimetti, Alex A. Aimetti InVivo Therapeutics Corporation, One Kendall Square Building 1400 East, Floor 4, Cambridge, MA, 02139 USASearch for more papers by this authorRobert Langer, Corresponding Author Robert Langer Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USAE-mail: [email protected]Search for more papers by this author Timothy M. O'Shea, Timothy M. O'Shea Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USASearch for more papers by this authorMatthew J. Webber, Matthew J. Webber David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115 USASearch for more papers by this authorAlex A. Aimetti, Alex A. Aimetti InVivo Therapeutics Corporation, One Kendall Square Building 1400 East, Floor 4, Cambridge, MA, 02139 USASearch for more papers by this authorRobert Langer, Corresponding Author Robert Langer Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USAE-mail: [email protected]Search for more papers by this author First published: 18 June 2015 https://doi.org/10.1002/adhm.201500334Citations: 19Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and ­controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and ­lyophilization stressors. Strong and ­ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. 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