Clinical Immunology: Principles and Practice

VOLUME 1 Section 1 - Principles of immune recognition. The human immune response. Cells and tissues of the immune system. Lymphocyte adhesion and trafficking. B cells antigen receptor genes, gene products and co-receptors. T cells antigen receptor genes, gene products and co-receptors. The major histocompatibility complex. Antigens and antigen presentation. T cell development. B cell development and differentiation. T lymphocyte activation and inactivation. Immunological tolerance and apoptosis. Cytokines and cytokine receptors. Chemokines and chemokine receptors. Section 2 - Host defense mechanisms and inflammation. Immunological function. Regulation of immune responses. T-cell mediated inflammation. Cytotoxic T cell function. Natural killer cells. Macrophage effector function. Host defenses at mucosal surfaces. Complement. Neutrophils. Mast cells and basophils, Eosinphils. Section 3 - Infection and immunity. Immune responses to extracellular bacteria. Immune responses to intracellular bacteria. Immune responses to spirochetes. Immune responses to viruses. Immune responses to protozoa. Immune responses to helminth infection. Immune responses to fungi. Infections in the immunocompromised host. Section 4 - Congenital and acquired deficiencies. Approach to the evaluation of the immunodeficient patient. Primary antibody deficiencies. Primary T cell immunodeficiencies. Complement deficiencies. Phagocyte deficiencies. Acquired immunodeficiency syndrome. HIV infection and AIDS in children. The fetal and neonatal immune system. Aging and the immune system. Immune deficiencies in hereditary and metabolic diseases. Immune abnormalities secondary to infectious diseases. Secondary immunodeficiency induced by surgery or trauma. Section 5 - Allergic diseases. The allergic response in host defence. Anaphylaxis. Allergic and other reactions to insects. Allergic rhinitis. Pathogenesis of asthma. Management of the asthmatic patient. Allergic skin diseases and contact dermatitis. Allergic gastrointestinal diseases. Allergic disorders of the eye. Drug allergies and hypersensitivity. Mastocytosis. Eosinophilia. Occupational asthma and related disorders. VOLUME 2 Section 6 - Systemic immune diseases. Mechanisms of autoimmunity and immunopathology. Serum sickness and pathophysiology of immune complexes. Systemic lupus erythematosus. Rheumatoid arthritis. Juvenile rheumatoid arthritis. Sjogren syndrome. Systemic sclerosis. Inflammatory muscle diseases. Spondyloarthropathies. Small and medium vessel primary vasculitides. Large vessel vasculitides. Rheumatic fever. Lyme disease. Amyloidosis. Section 7 - Organ-specific inflammatory diseases. Immune-mediated anemia. Immune-mediated neutropenia. Immune-mediated platelet coagulation disorders. Bulous skin disease. Myasthenia gravis. Multiple sclerosis and related diseases. Autoimmune peripheral neuropathies. Immunologic renal diseases. Myocardial inflammation. Autoimmune thyroid disease. Immunology of diabetes and related autoimmune endorcinopathies. Reproductive immunology. Immunologic lung diseases. Sarcoidosis. Immunologic ocular disease. Immunological diseases of the gastrointestinal tract. Inflammatory hepatobiliary disease. Section 8 - Solid organ transplantation. Concepts and challenges in solid organ transplantation. Renal transplantation. Heart and lung transplantation. Liver transplantation. Section 9 - Immunology of neoplasia. Anlympoproliferative disorders. Acute lymphoblastic leukemia. Chronic lymphocytic leukemia. Lymphoma and Hodgkin's disease. Virus-associated B cell tumours. Virally induced T cell malignancies and associated diseases. Monoclonal gammopathies. Immune responses and immunotherapy of cancer. Section 10 - Prevention and therapy of immunologic diseases. Bone marrow reconstitution in primary immunodeficiency. Bone marrow transplantation for malignant disease. Immunoglobulin replacement therapy in immunodeficiency diseases. Gene therapy: applications for immunodeficiency and cancer. Glucocorticoids. Non-steroidal anti-inflammatory drugs. Leukotriene inhibitiors. Antihistamines. Immunomodulating pharmaceuticals. Immunophilin binding agents. Vaccines. Immunotherapy of allergic diseases. Colony stimulating factors. Immune modulation: interferons and interleukins. Cytokine inhibitors and receptor antagonists. Monoclonal antibodies and immunoconjugates. Apheresis. Experimenatl immunotherapy of autoimmune disease. Section 11 - Diagnositic immunology. Assessment of immunoglobins and antibodies. Flow cytometry. Assessment of lymphocyte and monocyte function. Assessment of neutrophil function. Assessment of human allergic diseases. Molecular methods. HLA typing. Immunohematology.