Fabrication of Nanoscale Gas–Liquid Interfaces in Hydrophilic/Hydrophobic Nanopatterned Nanofluidic Channels

Gas-liquid interfaces (GLIs) are ubiquitous and have found widespread applications in a large variety of fields. Despite the recent trend of downscaling GLIs, their nanoscale fabrication remains challenging because of the lack of suitable tools. In this study, a nanofluidic device, which has undergone precise local surface modification, is used in combination with tailored physicochemical effects in nanospace and optimized nanofluidic operations, to produce uniform, arrayable, stable, and transportable nanoscale GLIs that can concentrate molecules of interest at the nanoscale. This approach provides a delicate nanofluidic mechanism for downscaling gas-liquid interfaces to the nanometer scale, thus opening up a new avenue for gas-liquid interface studies and applications.