Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels

孟德尔随机化 痛风 内科学 2型糖尿病 胰岛素抵抗 医学 优势比 血糖性 内分泌学 糖尿病 遗传倾向 稳态模型评估 胰岛素 尿酸 基因型 生物 遗传学 遗传变异 疾病 基因
作者
Jiahao Zhu,Lingling Sun,Jing Yang,Jiaqi Fan,Lap Ah Tse,Yingjun Li
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [The Endocrine Society]
卷期号:106 (7): e2547-e2556 被引量:7
标识
DOI:10.1210/clinem/dgab200
摘要

Abstract Purpose Previous epidemiological evidence showed that type 2 diabetes (T2D) is related with gout. However, the causality and the direction of this association are still not definitely elucidated. We investigated bidirectional associations of T2D and glycemic traits with serum urate concentrations and gout using a Mendelian randomization approach. Methods Summary statistics from the large-scale genomewide association studies conducted for T2D (Ncase = 62 892, Ncontrol = 596 424), fasting glucose (N = 133 010), fasting insulin (N = 133 010), hemoglobin A1c (N = 123 665), homeostasis model assessment of insulin resistance (N = 46 186), urate (N = 110 347), and gout (Ncase = 2115, Ncontrol = 67 259) among participants of European ancestry were analyzed. For each trait of interest, independent genomewide significant (P < 5 × 10−8) single nucleotide polymorphisms were selected as instrumental variables. The inverse-variance weighted method was used for the primary analyses. Results Genetic predisposition to higher risk of T2D [beta = 0.042; 95% confidence interval (CI) = 0.016-0.068; P = 0.002] and higher levels of fasting insulin (beta = 0.756; 95% CI = 0.408-1.102; P = 1.96e-05) were significantly associated with increased serum urate concentrations. Moreover, we found suggestively significant evidence supporting a causal role of fasting insulin on risk of developing gout (odds ratio = 3.06; 95% CI = 0.88-10.61; P = 0.078). In the reverse direction analysis, genetic predisposition to both urate and gout were not associated with T2D or any of 4 glycemic traits being investigated. Conclusions This study provides supportive evidence on causal associations of T2D and fasting insulin with serum urate concentrations and a suggestive association of fasting insulin with risk of gout. Future research is required to examine the underlying biological mechanisms on such relationships.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
苦西迪发布了新的文献求助10
刚刚
落后访风完成签到,获得积分10
1秒前
tg2024完成签到,获得积分10
2秒前
清脆的飞丹完成签到,获得积分10
3秒前
ycd完成签到,获得积分10
5秒前
liberation完成签到 ,获得积分10
8秒前
王sir完成签到 ,获得积分10
8秒前
11秒前
许大脚完成签到 ,获得积分10
12秒前
Accepted完成签到,获得积分10
12秒前
iboy完成签到,获得积分20
12秒前
饼饼完成签到,获得积分10
13秒前
畅快的胡萝卜完成签到,获得积分10
13秒前
g7001完成签到,获得积分10
13秒前
phil完成签到,获得积分10
16秒前
iboy发布了新的文献求助10
16秒前
chawenxian2025完成签到 ,获得积分10
19秒前
梦XING完成签到 ,获得积分10
19秒前
moxin完成签到,获得积分10
19秒前
自由的中蓝完成签到 ,获得积分10
19秒前
大饼完成签到,获得积分10
21秒前
WenzongLai完成签到,获得积分10
23秒前
研友_5Zl9D8完成签到,获得积分10
24秒前
fishss完成签到,获得积分10
24秒前
CipherSage应助一个小胖子采纳,获得10
24秒前
24秒前
睡不醒也吃不饱完成签到 ,获得积分10
25秒前
三颗石头完成签到,获得积分10
25秒前
既然寄了,那就开摆完成签到 ,获得积分10
27秒前
确幸完成签到,获得积分10
27秒前
27秒前
BENLAI发布了新的文献求助10
27秒前
淡然水绿完成签到,获得积分10
28秒前
yellow完成签到 ,获得积分10
30秒前
肖窈应助liyu采纳,获得10
31秒前
yongzaizhuigan完成签到,获得积分10
33秒前
心有猛虎完成签到,获得积分10
34秒前
简单的铃铛完成签到 ,获得积分10
35秒前
36秒前
黑猫警长完成签到,获得积分10
37秒前
高分求助中
Sustainability in Tides Chemistry 1500
Handbook of the Mammals of the World – Volume 3: Primates 805
拟南芥模式识别受体参与调控抗病蛋白介导的ETI免疫反应的机制研究 550
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Manual of Sewer Condition Classification 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3068355
求助须知:如何正确求助?哪些是违规求助? 2722240
关于积分的说明 7476332
捐赠科研通 2369299
什么是DOI,文献DOI怎么找? 1256310
科研通“疑难数据库(出版商)”最低求助积分说明 609538
版权声明 596835