膨胀的
佐剂
疫苗佐剂
叙述性评论
生物技术
医学
生化工程
计算生物学
生物
免疫学
重症监护医学
工程类
材料科学
抗压强度
复合材料
作者
Yizhi Qi,Christopher B. Fox
标识
DOI:10.1080/14760584.2021.1902314
摘要
The importance of vaccine thermostability has been discussed in the literature. Nevertheless, the challenge of developing thermostable vaccine adjuvants has sometimes not received appropriate emphasis. Adjuvants comprise an expansive range of particulate and molecular compositions, requiring innovative thermostable formulation and process development approaches.Reports on efforts to develop thermostable adjuvant-containing vaccines have increased in recent years, and substantial progress has been made in enhancing the stability of the major classes of adjuvants. This narrative review summarizes the current status of thermostable vaccine adjuvant development and looks forward to the next potential developments in the field.As adjuvant-containing vaccines become more widely used, the unique challenges associated with developing thermostable adjuvant formulations merit increased attention. In particular, more focused efforts are needed to translate promising proof-of-concept technologies and formulations into clinical products.
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