再生(生物学)
骨骼肌
肌发生
刺激
生物医学工程
机械转化
细胞生物学
医学
生物
解剖
内科学
作者
Bo Ri Seo,Christopher Payne,Stephanie L. McNamara,Benjamin R. Freedman,Brian J. Kwee,Sungmin Nam,Irene de Lázaro,Max Darnell,Jonathan T. Alvarez,Maxence O. Dellacherie,Herman H. Vandenburgh,Conor J. Walsh,David J. Mooney
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2021-10-06
卷期号:13 (614)
被引量:41
标识
DOI:10.1126/scitranslmed.abe8868
摘要
Mechanical stimulation (mechanotherapy) can promote skeletal muscle repair, but a lack of reproducible protocols and mechanistic understanding of the relation between mechanical cues and tissue regeneration limit progress in this field. To address these gaps, we developed a robotic device equipped with real-time force control and compatible with ultrasound imaging for tissue strain analysis. We investigated the hypothesis that specific mechanical loading improves tissue repair by modulating inflammatory responses that regulate skeletal muscle regeneration. We report that cyclic compressive loading within a specific range of forces substantially improves functional recovery of severely injured muscle in mice. This improvement is attributable in part to rapid clearance of neutrophil populations and neutrophil-mediated factors, which otherwise may impede myogenesis. Insights from this work will help advance therapeutic strategies for tissue regeneration broadly.
科研通智能强力驱动
Strongly Powered by AbleSci AI