母乳喂养
胎龄
队列
前瞻性队列研究
医学
队列研究
婴儿配方奶粉
人口学
儿科
婴儿发育
怀孕
生物
内科学
心理学
发展心理学
社会学
遗传学
作者
Ana Lorena Lima Ferreira,Nadya Helena Alves-Santos,Nathalia Freitas-Costa,Pedro Paulo Teixeira dos Santos,Mônica Araújo Batalha,Amanda C. Cunha Figueiredo,Chloe Yonemitsu,Nadia Manivong,Annalee Fürst,Lars Bode,Gilberto Kac
摘要
Human milk oligosaccharides (HMOs) are unconjugated glycans associated with infant health and development.To investigate the associations between HMO concentrations at 1 month and infant development throughout the first year of life.A prospective cohort of Brazilian women between 18-40 years of age and their infants was studied from baseline (between 28-35 gestational weeks) and followed at 1 (n = 73), 6 (n = 51), and 12 months (n = 45). A total of 19 HMOs were quantified by HPLC with fluorescence detection. Infant development was evaluated by the Brazilian Ages and Stages Questionnaire. A directed acyclic graph was used to define the minimally sufficient adjustment (gestational age at birth, gestational weight gain, prepregnancy BMI, maternal age, parity, and the mode of breastfeeding at 1 month). Cox regression models with HRs and Benjamini-Hochberg multiple corrections were performed to estimate associations of HMOs with the cumulative risk of inadequate development for 5 developmental domains or for ≥2 developmental domains in all women and in the subset of secretor women (defined as the presence or near absence of 2'-fucosyllactose and lacto-N-fucopentaose I).The multivariate models with multiple corrections revealed an inverse association between lacto-N-tetrose (LNT) and the risk of inadequate development for personal-social skills (0.06; 95% CI: 0.01-0.76) and for ≥2 developmental domains (0.06; 95% CI: 0.01-0.59). The secretor mothers analysis also showed inverse associations with slightly different results for personal-social skills (0.09; 95% CI: 0.02-0.84) and ≥2 developmental domains (0.05; 95% CI: 0.01-0.70).Higher concentrations of LNT HMOs in Brazilian women are associated with their infants being less likely to be at risk of inadequate development for personal-social skills or for ≥2 developmental domains during the first year of life.
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