We have previously shown that ecological factors markedly change modern female body proportions. In this study we investigated the role of internal vs. external factors on the maturation and physiological functions of accelerated female population. We monitored main physiological parameters (EKG, blood pressure, respiratory parameters etc.) vs. bone length and muscle plasticity of 410 healthy female individuals at the age 20–27 and 520- at the age 17–19. Our results demonstrated that anthropological features and functional stability as well as body proportion of modern female population were genetically inherited from their mothers. Early maturation at 9.5–11 years revealed significant changes in height weight and plasticity but not in physiological parameters (p<0.05). Late maturation-15–17 years, controversy, defined lower height and inadequate weight that could be considered as lack of environmental adaptation and inadequate physical activity and protein content in food supply. Sports training could partly compensate immature functions. In both groups subjects with scoliosis demonstrated lower physiological parameters (Student t-test <0.05). Level of poverty, chronic diseases and ecological pollution of places of living and studying has the impact on maturation and time set of menarche (p<0.05). Conclusions Height, weight and late maturation could serve as markers for physiological functions alteration. [CIHR and NIH].