A Pancreas-Specific Ptf1a-Driven Cre Mouse Line Causes Paternally Transmitted Germline Recombination

Since its discovery, 1 Sternberg N. et al. J Mol Biol. 1981; 150: 467-486 Google Scholar the Cre-loxP system has been highly used in mouse models, providing precision for both cell type and temporal selection of genetic manipulation. Although generally the method is powerful, a number of reports suggest limitations such as parental transmission of germline recombination with certain promoters used for initiation of Cre-expression. 2 Luo L. et al. Neuron. 2002; 106: 37-65 Google Scholar