精神分裂症(面向对象编程)
功能磁共振成像
重性抑郁障碍
心理学
双相情感障碍
功能连接
焦虑
失调家庭
研究领域标准
神经科学
生命银行
精神科
自闭症谱系障碍
神经影像学
自闭症
萧条(经济学)
心理健康
生物信息学
生物
认知
宏观经济学
经济
作者
Daniël Roelfs,Dennis van der Meer,Dag Alnæs,Oleksandr Frei,Alexey Shadrin,Robert Loughnan,Chun Chieh Fan,Anders M. Dale,Ole A. Andreassen,Lars T. Westlye,Tobias Kaufmann
出处
期刊:Cold Spring Harbor Laboratory - medRxiv
日期:2021-06-22
被引量:9
标识
DOI:10.1101/2021.06.15.21258954
摘要
Abstract Psychiatric disorders are complex, heritable, and highly polygenic. Supported by findings of abnormalities in functional magnetic resonance imaging (fMRI) based measures of brain connectivity, current theoretical and empirical accounts have conceptualized them as disorders of brain connectivity and dysfunctional integration of brain signaling, however, the extent to which these findings reflect common genetic factors remains unclear. Here, we performed a multivariate genome-wide association analysis of fMRI-based functional brain connectivity in a sample of 30,701 individuals from the UK Biobank and investigated the shared genetic determinants with eight major psychiatric disorders. The analysis revealed significant genetic overlap between functional brain connectivity and schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder, autism spectrum disorder, anxiety, and major depression, adding further genetic support for the dysconnectivity hypothesis of psychiatric disorders and identifying potential genetic and functional targets for future studies.
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