氧化损伤
荟萃分析
氧化应激
氧化磷酸化
医学
科学网
内科学
生理学
毒理
内分泌学
化学
男科
生物
生物化学
作者
Huan Zhang,Ruifu Yang,Wanying Shi,Xin Zhou,Suzhen Sun
标识
DOI:10.1016/j.envpol.2021.118444
摘要
Numerous studies reported that BPA could cause oxidative damage to different tissues in rats/mice. This study aimed to perform a systematic review and meta-analysis of BPA exposure on oxidative damage in rats/mice. A comprehensive literature search was conducted using PubMed, Embase, and Web of Science databases from their inception date until July 18, 2020.20 eligible articles were included in this study. The results showed that BPA could significantly increase the level of MDA (SMD, 16.88; 95%CI, 12.06-21.71), but there was a significant reduction in the contents of antioxidants, such as GR (-10.46, -13.91 ∼ -7.02), CAT (-8.48, -11.66 ∼ -5.30), GPx (-9.73, -11.95 ∼ -6.80), GST (-7.59, -14.51 ∼ -0.67), GSH (-11.41, -15.10 ∼ -7.72), and SOD (-6.48, -8.37 ∼ -4.58) in rats/mice. Our study provided clear evidence that BPA exposure could significantly induce oxidative damage in rats/mice. And we also found that the degree of oxidative damage was related to BPA dose, target tissue, intervention means, and exposure duration of BPA.
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