Brain network dynamics are hierarchically organized in time

Significance We address the important question of the temporal organization of large-scale brain networks, finding that the spontaneous transitions between networks of interacting brain areas are predictable. More specifically, the network activity is highly organized into a hierarchy of two distinct metastates, such that transitions are more probable within, than between, metastates. One of these metastates represents higher order cognition, and the other represents the sensorimotor systems. Furthermore, the time spent in each metastate is subject-specific, is heritable, and relates to behavior. Although evidence of non–random-state transitions has been found at the microscale, this finding at the whole-brain level, together with its relation to behavior, has wide implications regarding the cognitive role of large-scale resting-state networks.