亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Focused ultrasound–mediated noninvasive blood-brain barrier modulation: preclinical examination of efficacy and safety in various sonication parameters

超声 血脑屏障 薄壁组织 超声波 微气泡 医学 埃文斯蓝 生物医学工程 聚焦超声 中枢神经系统 病理 内科学 放射科
作者
Jaewoo Shin,Chanho Kong,Jae Sung Cho,Jihyeon Lee,Chin Su Koh,Min-Sik Yoon,Young Cheol Na,Won Seok Chang,Jin Woo Chang
出处
期刊:Neurosurgical Focus [American Association of Neurological Surgeons]
卷期号:44 (2): E15-E15 被引量:71
标识
DOI:10.3171/2017.11.focus17627
摘要

OBJECTIVE The application of pharmacological therapeutics in neurological disorders is limited by the ability of these agents to penetrate the blood-brain barrier (BBB). Focused ultrasound (FUS) has recently gained attention for its potential application as a method for locally opening the BBB and thereby facilitating drug delivery into the brain parenchyma. However, this method still requires optimization to maximize its safety and efficacy for clinical use. In the present study, the authors examined several sonication parameters of FUS influencing BBB opening in small animals. METHODS Changes in BBB permeability were observed during transcranial sonication using low-intensity FUS in 20 adult male Sprague-Dawley rats. The authors examined the effects of FUS sonication with different sonication parameters, varying acoustic pressure, center frequency, burst duration, microbubble (MB) type, MB dose, pulse repetition frequency (PRF), and total exposure time. The focal region of BBB opening was identified by Evans blue dye. Additionally, H & E staining was used to identify blood vessel damage. RESULTS Acoustic pressure amplitude and burst duration were closely associated with enhancement of BBB opening efficiency, but these parameters were also highly correlated with tissue damage in the sonicated region. In contrast, MB types, MB dose, total exposure time, and PRF had an influence on BBB opening without conspicuous tissue damage after FUS sonication. CONCLUSIONS The study aimed to identify these influential conditions and provide safety and efficacy values for further studies. Future work based on the current results is anticipated to facilitate the implementation of FUS sonication for drug delivery in various CNS disease states in the near future.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
23秒前
迷茫的一代完成签到,获得积分10
59秒前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
1分钟前
无私的薯片完成签到,获得积分20
1分钟前
科研通AI2S应助科研通管家采纳,获得30
2分钟前
无花果应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
可爱的函函应助Lorain采纳,获得10
2分钟前
2分钟前
huangwensou发布了新的文献求助30
2分钟前
5Hepburn发布了新的文献求助10
2分钟前
ZXH发布了新的文献求助10
2分钟前
5Hepburn完成签到,获得积分20
2分钟前
2分钟前
3分钟前
李健的小迷弟应助凉白开采纳,获得10
3分钟前
钟垠州完成签到 ,获得积分10
3分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
Lorain发布了新的文献求助10
3分钟前
herococa完成签到,获得积分0
3分钟前
3分钟前
3分钟前
4分钟前
4分钟前
Lorain发布了新的文献求助10
4分钟前
隐形曼青应助Lorain采纳,获得10
4分钟前
krajicek发布了新的文献求助10
4分钟前
Lorain发布了新的文献求助10
4分钟前
量子星尘发布了新的文献求助10
4分钟前
4分钟前
凉白开发布了新的文献求助10
5分钟前
5分钟前
Lorain发布了新的文献求助10
5分钟前
5分钟前
5分钟前
6分钟前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3960135
求助须知:如何正确求助?哪些是违规求助? 3506271
关于积分的说明 11128683
捐赠科研通 3238299
什么是DOI,文献DOI怎么找? 1789684
邀请新用户注册赠送积分活动 871870
科研通“疑难数据库(出版商)”最低求助积分说明 803069