Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury

传出细胞增多 炎症 支气管肺泡灌洗 巨噬细胞 细胞凋亡 脂质信号 肺泡巨噬细胞 脂质代谢 吞噬作用 药理学 免疫学 医学 化学 内科学 体外 生物化学
作者
Hiroki Kimura,Masaru Suzuki,Satoshi Konno,Hideo Shindou,Takao Shimizu,Takahide Nagase,Toru Miyazaki,Masaharu Nishimura
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:199 (11): 3870-3882 被引量:27
标识
DOI:10.4049/jimmunol.1601798
摘要

Abstract Appropriate resolution of inflammation is known to be essential in tissue homeostasis. In this study, we evaluated the significance of a macrophage-derived soluble protein, apoptosis inhibitor of macrophage (AIM), in LPS-induced lung injury in mice. After oropharyngeal administration of LPS, the level of free-form serum AIM increased on days 2–4, accompanied by the resolution of inflammation, which was observed in the cellular profile of bronchoalveolar lavage fluid. In an experiment using wild-type (WT) and AIM−/− mice, the resolution of inflammation was accelerated in AIM−/− mice when compared with the WT mice, which was reversed when recombinant AIM protein was administered. The changes in the histopathological findings and inflammatory mediators followed similar trends, and the ratio of apoptotic cells was increased in AIM−/− mice when compared with the WT mice. In vitro analysis showed that macrophage phagocytosis of apoptotic neutrophils was suppressed in the presence of AIM, indicating that anti-resolution property of AIM involves efferocytosis inhibition. In lipidomic analysis of lung tissues, the levels of several lipid mediators increased markedly when LPS was given to WT mice. However, in AIM−/− mice, the concentrations of these lipid mediators were not significantly upregulated by LPS. These data reflect the significant role of AIM in lipid metabolism; it may suppress lipid metabolites at baseline, and then produce an inflammatory/pathologic pattern in the event of LPS-induced lung injury. Taken together, AIM may play an orchestrating role in the resolution process of inflammation by altering the profile of pulmonary lipid mediators in mice.
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