Synthesis of 1,2-diacyloxypropyl-3-(1′,2′-diacyl-sn-glycero)-phosphonate

The total synthesis of 1,2-diacyloxypropyl-3-(1′,2′-diacyl-sn-glycero)phosphonate is described. The 1,2-dipalmitoyloxypropyl phosphonic acid was prepared by an Arbusov reaction of 1,2-diacylglycerol bromohydrin with trimethyl phosphite; the final product was obtained by a coupling reaction involving the diacyloxypropyl-3-phosphonic acid and 1,2-dipalmitoyl-sn-glycerol, catalysed by tri-isopropylbenzene sulfonyl chloride. The resulting synthetic product was characterised by elemental analysis, phosphono-phosphorus determinations and IR spectroscopy.