褪黑素
氧化应激
胆汁淤积
医学
丙二醛
抗氧化剂
超氧化物歧化酶
内科学
谷胱甘肽
内分泌学
过氧化氢酶
脂质过氧化
酶
生物化学
化学
作者
A. Cruz,Inmaculada Tasset,Luz María Ramírez,Álvaro Arjona‐Sánchez,José Segura,Isaac Túnez,Pedro Montilla,Jordi Muntané,Javier Padillo‐Ruiz
标识
DOI:10.4321/s1130-01082009000700002
摘要
melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions.we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 microg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue.obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium.melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.
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