Method for the determination of the total fluorine content of whole blood, serum/plasma, and other biological samples

A procedure for the determination of total fluorine in whole blood, serum/plasma, and other biological samples is described. The method is based on oxygen bomb combustion reaction with triethylsilanol, and gas chromatography. By eliminating the combustion step, only ionic or acid-labile fluoride is measured. The difference between the two results gives the organic or "bound" fluoride level of the sample.